It is an ICH E6 requirement that the investigator should document his qualifications, training and experience in an up to date CV.
4.1 Investigator's Qualifications and Agreements,
Item 4.1.1 states
"The investigator(s) should be qualified by education, training, and experience to assume responsibility for the proper conduct of the trial, should meet all the qualifications specified by the applicable regulatory requirement(s), and should provide evidence of such qualifications through up-to-date curriculum vitae"

What constitutes an up-to-date CV? does the CV require signing and dating?