Fetal Genotyping

[Rashmi]

As many sites are going over to referring samples from their RhD Neg antenatal patients for fetal genotyping, perhaps we could share some ideas on what has been problematic or works well.

How is the result of the fetal genotype recorded on your LIMS?

If the patient miscarries and then soon after is again pregnant- how do you differentiate the fetal genotype of pregnancy 1 and pregnancy 2- to avoid confusion to both clinical and lab staff?

many thanks

[Lumuss]

I have been working with SensiGene Fetal RHD Genotyping. I can share some of the materials (I will ask for an official permission to share those on forums though). If it's allowed here, I could upload my lab reports to a Google Drive with full access.
Update: I have just received an official permission from eviCore and as soon as I finish archiving data, I will upload the materials here.



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[EClarke]

Great question Rashmi . What about twins or multiple births.

[Rashmi]

It would be interesting to see the results of these- but I dont think there would not be an issue with detection, and any trends would be identified by SHOT.
As with any change its always a good idea to apply 'Murphys Law' - if something can go wrong, given the chance it will, and to design our systems to try and prevent any adverse effects. Of course nowadays its called change control