I am working for a French pharmaceutical company, and we are thinking on the same question: one of our vendors has only manual signature process and we have a possibility to sign electronically. Shipping documents across the country is neither cost and time effective nor environmentally friendly. From my previous experience in a CRO I remember that mixing up the wet ink and electronic signature was acceptable as long as the handwritten one comes first. Since signaling a document electronically encodes the document, doing overwise would invalidate the eSignautre. What do you think on this approach?